Hi Pablo.
I think you will find this link to be useful:
In this package take a look at basic_set_external_file_reputation.py -- in this script, it checks to see if a hash already exists in TIE and is not, sets a reputation. I took this script and added a list of hashes from a file and set as malicious.
There are other example scripts such as get a reputation as well.
Hope this helps,
Pete